Brain atrophy in clinically early relapsing–remitting multiple sclerosis
نویسندگان
چکیده
منابع مشابه
Rate of brain atrophy in benign vs early multiple sclerosis.
BACKGROUND Benign multiple sclerosis (MS) is defined by minimal or no disability after many years of observation, therefore a less degenerative disease process is suspected to be present in this subset of patients. OBJECTIVE To compare brain atrophy rates in patients with long-standing benign MS vs typical early MS. DESIGN A longitudinal prospective cohort study and a retrospective database...
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Putamen atrophy and its long-term progress during disease course were recently shown in patients with multiple sclerosis (MS). Here we investigated retrospectively the time point of atrophy onset in patients with relapsing-remitting MS (RRMS). 68 patients with RRMS and 26 healthy controls (HC) were admitted to 3T MRI in a cross-sectional study. We quantitatively analyzed the putamen volume of i...
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We used cross-sectional tensor-based morphometry to visualize reduced volume in the whole brains of pediatric patients with multiple sclerosis, relative to healthy controls. As a marker of local volume difference, we used the Jacobian determinant of the deformation field that maps each subject to a standard space. To properly assess abnormal differences in volume in this age group, it is necess...
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UNLABELLED The aim of this study was to investigate if brain atrophy in multiple sclerosis (MS) patients during the disease onset predicts long term disability. METHODS MS patients with follow-up time of at least 7 years from disease onset and with baseline and second magnetic resonance 12 months later were included to measure brain atrophy. Expanded Disability Status Scale (EDSS) was categor...
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M ultiple sclerosis (MS) is a chronic inflammatory demyelinating disease affecting the central nervous system (CNS) characterized by a relapsing-remitting course in the majority of the patients. In the last two decades, an increasing number of approved drugs for MS showed efficacy on clinical relapses and magnetic resonance imaging (MRI) lesions related to inflammatory activity in the CNS. Alth...
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ژورنال
عنوان ژورنال: Brain
سال: 2002
ISSN: 1460-2156,0006-8950
DOI: 10.1093/brain/awf025